A dominating frontcourt presence throughout the mid-1980s, Bruce Lefkowitz finished his career with 1,443 points, which at the time of his graduation placed him fifth on Penn's all-time scoring chart and still has him 11th all-time within the program. His career field-goal percentage was 58.7, which to this day remains second all-time at Penn -- a stat enhanced by the fact that he took more shots than any of the top six listed in that category.
 
Lefkowitz led Penn in scoring in both his junior and senior seasons, averaging 14.2 points per game in 1985-86 and 18.7 in 1986-87. A four-year starter, he led the Quakers in rebounding all four years he played, a feat that has never been duplicated in the annals of Penn basketball.

Lefkowitz was first-team All-Ivy as a senior, second-team All-Ivy as a junior, and All-Ivy honorable mention as a sophomore. He was second-team All-Big 5 as a senior. As a freshman, Lefkowitz was honored with the program's G. Fred DiBona Award as the program's outstanding newcomer.

Penn won a pair of the Ivy League titles during Lefkowitz's career, in 1984-85 and his senior year of 1986-87 (he was a captain of that team). The Quakers went 10-4 both of those seasons. His junior year, the Red and Blue went 9-5 in league play and tied for second place.

Following his Penn career, Lefkowitz played professionally for the Philadelphia Aces of the United States Basketball League (USBL). In 2009, he was elected to the Westchester County (N.Y.) Athletics Hall of Fame.